Aphios
Presents “Phospholipid Nanosomes and Polymer Nanospheres
for the Nanotechnology Delivery of Biologics, siRNA and
Hydrophobic Anticancer Drugs” at the 240th
ACS (American Chemical Society) National Meeting in
Boston, Massachusetts
August
24 , 2010
— Phospholipid
nanosomes are small, uniform liposomes manufactured utilizing
SuperFluids™ (supercritical fluids, critical or near-critical
fluids with and without polar cosolvents such as ethanol).
SuperFluids™
are first used to solvate phospholipid raw materials, and
then decompressed to form phospholipid nanosomes that can
encapsulate hydrophilic molecules such as therapeutic proteins
and siRNA. Hydrophobic therapeutics such as Taxol are co-solvated
with phospholipids in SuperFluids™ that, when decompressed,
form phospholipid nanosomes encapsulating them in lipid
bilayers. Phospholipid nanosomes can also be used to co-encapsulate
hydrophilic and hydrophobic drugs such as Tdp1 and Top1
inhibitors for drug resistant cancers.
Polymer
nanospheres comprising of hydrophobic biodegradable copolymers
are also by manufactured by SuperFluids™. These nanospheres
can be used for the oral delivery of therapeutic proteins
such as insulin, hydrophobic anticancer drugs and small
molecules such as Δ9-THC as well as the controlled
release of viral (HIV and influenza) and bacterial (anthrax)
antigens for vaccines.
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