Aphios Corporation

Material Safety Data Sheet — Palitaxel

Product Name: Paclitaxel

Identification: Chemical Name: 5ß, 20-epoxy-1,2a,4,7ß, 10ß, 13a-hexahydroxytax-11-en-9-one, 4,10-diacetate 2-benzoate 13-ester with (2R, 3S)-N-benzoyl-3-phenylisoserine
CAS Number: 33069-62-4 NSC: 125973
Chemical Family: Taxane Diterpenes (Taxoids)
Molecular Formula: C₄₇H₅₁NO₁₄
Molecular Weight: 853.9

Physical Data: Appearance: Odorless white solid

Solubility: DMSO, methanol, acetonitrile, ethanol. Insoluble in water. Melting Point: 213-216° C

Hazardous Ingredient: Paclitaxel Percent: >99%

Ingredients: May contain traces of other naturally occurring compounds in the needles of the ornamental yew plant.

Toxicological Information: RTECS Number: WX1272100
Toxicity Data and References:
IV-dog: LD = 15mg/kg Behavioral: Effects on lungs, thorax, or respiration. NTIS**PB83-170969
IP-rat: LD =33 mg/kg Behavioral: Effects on lungs, thorax, or respiration; Nutritional and
gross metabolic. NTIS**PB83-170969
IP-mouse: LD = 128 mg/kg Skin and Appendages; Nutritional and gross metabolic. NTIS**PB83-170969
IV-mouse: LD = 12 mg/kg Behavioral: Effects on lungs, thorax, or respiration. PHREEB 4:162, 1987
Exposure limits: Not yet established

Health Hazard Data: Compound may be harmful if ingested, inhaled, or absorbed through the eyes or skin.

First Aid: For EYE contact: Flush with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. Consult a physician. For SKIN contact: Wash with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes and wash before rewearing. Consult a physician. For INHALATION: Remove to fresh air and monitor breathing. If breathing becomes difficult or signs of toxicity exist, consult a physician. For INGESTION: Consult the local poison center and a physician.

Fire & Explosion Data: Flash point: n.a. Extinguishing media: Dry chemical powder, carbon dioxide, polymer foam, or water spray. Unusual fire or explosion hazards: Upon thermal decomposition, may emit toxic gases including carbon monoxide, carbon dioxide. Special fire fighting procedures: Wear self-contained breathing apparatus and full protective clothing to prevent contact with eyes and skin.

Stability & Reactivity Data: Stability: Stable under normal handling conditions up to 170° C Incompatibilities and conditions to avoid: avoid contact with strong acids and bases. Store away from oxidizing agents. Protect from light and humidity. Hazardous combustion or decomposition products: Upon thermal decomposition, may emit toxic gases such as carbon monoxide.

Handling & Storage: Store in a tightly closed container, with desiccant @-20° C. Protect from light and oxidizing agents. Avoid contact with the material and avoid prolonged or repeated exposure. Wash hands thoroughly after handling material.

Spill & Leak Procedures: Evacuate the area and ventilate. Wear protective clothing as outlined below. Avoid raising aerosols by promptly covering with absorbent material. Sweep up and place in a suitable container. Dispose of properly. Wash spill site with soap and water.

Waste Disposal: Observe all Federal, state and local laws concerning the disposal of hazardous material or waste.

Special Protection Information: Protective equipment: Wear suitable protective clothing, chemical resistant rubber gloves, rubber boots, and chemical safety goggles. Respiratory protection and Ventilation: Self-contained breathing apparatus or NIOSH/MSHA approved respirator. Handle in a chemical fume hood with adequate ventilation.

Additional Precautions & Comments: Material should be handled only by qualified, experienced personnel. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. APHIOS Corporation shall not be held liable for any damage resulting from handling or from contact with the above product. See invoice or packing slip for additional terms and conditions of sale.