Polymer Nanospheres – PNS
For oral/depot/intravenous delivery of proteins and hydrophobic molecules, and controlled-release small molecules and vaccine antigens
Hydrophobic Microspheres – The Opportunity and the Problems
Biologically adherent polymeric microsphere carriers have been shown to be effective in the oral delivery of proteins such as insulin and DNA plasmids. These microspheres are comprised of hydrophobic copolymers, in contrast to conventional microspheres that are hydrophilic in nature. The hydrophobic microspheres appear to have a significantly longer residence time in the gastrointestinal tract compared to conventional microspheres.
While highly promising, the hydrophobic microspheres still present challenges in terms of manufacturing and formulation of a clinically acceptable product. Typically, the microspheres are produced from an organic solvent solution, which raises concerns about deleterious effects on the therapeutic protein and residual organic solvent in the final product.
A Solution - SuperFluids™ Polymer Nanospheres - PNS
Aphios has avoided these difficulties by utilizing supercritical, critical or near-critical fluids with or without polar cosolvents (SuperFluids™ [SFS]) to form mono-disperse Polymer Nanospheres (PNS). These nanospheres are utilized to encapsulate proteins with controlled-release characteristics without usage of toxic organic solvents.
The PNS Process
The PNS biodegradable polymer nanospheres technology platform can be used for the oral delivery of therapeutic proteins and the subcutaneous controlled release of vaccine antigens.
Contact us if you are interested in conducting a feasibility study and/or establishing a research and development partnership.